The pharmaceutical companies like statistics because with statistics, they know you can make convincing arguments for taking their drug. Statins are a classic example of this problem. Advertising and even some physicians will tell patients that taking statins will decrease the risk of a major cardiac event by 30%. Wow, does that mean that it helps about one in three patients?....Nope. That would be a very convincing statistic if that is what it meant but that is also very deceptive. It is true about the 30% reduction but lets look at what it really means. In a meta-analysis of 42,000 patients from 7 separate studies there was a 29% reduction in major cardiac events over a 3-5 year period but the number of major cardiac events in this population was very low. A more understandable way to look at this study is that 60 patients would need to take statins for 4.3 years in order to protect one person from a single heart attack. This is what is called Number Needed to Treat or NNT.
The NNT is the average number of patients who need to be treated to prevent one additional bad outcome (i.e. the number of patients that need to be treated for one to benefit compared with a control in a clinical trial). - Wikipedia
So what about the other 59 patients taking the statin? Well, nearly all of them experienced some degreee of frailty or mental decline.
Let's look at some other studies on the NNT for statin drug use:
Statins x 5 years - without known heart disease
- 98% saw no benefit
- 0% saved from death
- 1.6% prevented heart attack
- 0.4% stroke prevention
- 1.5% developed diabetes
- 10% developed muscle damage
So,
- None were actually saved
- 1 in 60 had heart attack prevented
- 1 in 67 developed diabetes
- 1 in 10 experienced muscle damage
Other studies for NNT of statins to prevent one heart attack have shown;
- Patients with previous heart attack or known heart disease NNT ranges 16-23
- Patients with no previous heart attack but have risk factors NNT 70-250
- To prevent death with no previous heart attack but with risk factors NNT = 500+
This would not be that big of a deal if it were not for the fact that statins pose a great risk of toxicity. Adverse outcomes occur more commonly than benefits and these include; rhabdomyolysis (muscle wasting), liver damage, diabetes, ALS (yes, Lou Gehrigs disease us much more common in statin users), heart failure, arthritis, memory problems, Parkinson's disease, neuropathy, and dementia. The body makes horrible sacrifices for the benefit of the heart when taking statins. Think about the fact that despite the brain only making up 2% of our body weight, it contains 25% of our total body cholesterol. Multiple studies have demonstrated the detrimental effects of statins on the brain - depression, confusion, dementia, memory loss, Parkinson's, and ALS.
Statin drugs inhibit an enzyme called HMG CoA reductase which is part of an early step in the 25 step process to create cholesterol. Unfortunately this enzyme is involved in multiple other very important physiologic processes in our body. It is a big component of metabolism and energy utilization, especially when it comes to Coenzyme Q10. When CoQ10 is impaired then muscle energy physiology is drastically altered, this accounts for much of the muscular dysfunction in patients treated with statins. Also this does not have to be a frankly obvious symptom when one first starts taking the drug, it will work insidiously at gradually destroying your muscle over time.
We need to develop a new understanding that cholesterol is not the villain that we have made it out to be. In fact, it is a life essential friend to the body. Cholesterol is an important structural component to the cell wall of every cell in our body, it is involved in ion transport in cells, it is the precursor to vitamin D3, it makes up our sex hormones (testosterone, estrogen, and progesterone), and cortisol.
Based on statin's mechanism of action we can expect with longer use leading to frailty, mental decline and death. I also would like to mention one other NNT study;
Prevention of second heart attack in patients following and adhering to the Mediterranean diet after their first heart attack = 18!
- Side affects = 0
- Prevented cancer NNT 30
- Prevented death NNT 30
I can only imagine what the NNT would be for paleo diet with regard to heart disease, diabetes, and cancer.
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